Normally they are found at their highest concentrations in dark chocolate. It is well documented that cocoa and chocolate polyphenolic polymers are among the richest sources of procyanidins.
In vivo studies in mice using polyphenols revealed that pancreatic cancer cells selectively underwent apoptosis while non-diseased tissue was unaffected. Experimental evidence has revealed NF-kB, PI 3-kinase and ROS-generators as cell survival targets that are attenuated in this approach. In contrast, the mitochondrial permeability transition pore and caspases have been identified as molecular targets that are responsible for triggering apoptosis.
This discovery can potentially be used for the treatment of other cancers, as well as for sensitizing refractory tumors to chemotherapeutic and/or radiation therapies.
ADVANTAGES
- A combination of polyphenols and ROS inhibitors dramatically reduces tumor size and inhibits tumor metastasis in a pancreatic cancer mouse model.
- The polyphenol rottlerin is effective without added ROS inhibitors.
- Non-diseased tissue is unaffected in in vivo studies in mice.
- There is no immunological response since cells die via apoptosis.
- There is no apparent toxicity.
- Potential treatment for pancreatic cancer.
- Potential to sensitize refractory cancer cells to other treatments.
- May be applicable to other cancers.
- Possible utility as a preventative for pancreatic cancer
Research is indicating that not only is eating dark chocolate a good strategy for preventing pancreatic cancer, but also a host of other degenerative diseases brought on by our life styles, unhealthy environment, and the foods we ingest. All chocolate is not the same.
HEALTH BENEFITS
It is well documented that cocoa and chocolate polyphenolic polymers are among the richest sources of procyanidins. It is one of the most complex food substances on earth containing over 300 chemically identifiable compounds. These beans are packed with potent antioxidants called flavonoids which boost numerous health benefits, reduce blood pressure, and decreases the body's inflammatory immune responses (which contribute to atherosclerosis)
COMPARED TO WHAT?
When a dark chocolate bar states 70% cocoa on the label it does not mean it is rich in flavonoids or nutrients. All "store bought" chocolate is heat processed which destroys most nutrients. In addition, they often contain high calories, bad fats, chemical fillers, waxes, added sugars and caffeine plus preservatives!
References:
POLYPHENOLIC COMPOUNDS INHIBIT PANCREATIC CANCER
